α-Lipoic acid 300 mg 2x day
Acetyl-L-Carnitine 2,000 mg a day
Inositol (500-1,000 mg a day)
B6 (50-100 mg a day)
B12 (500-5,000 mcg a day
Vitamin B complex helps to alleviate degeneration in the nervous system and vitamin B1 (thiamine), vitamin B6 (pyridoxine) in combination with vitamin B12 are clinically administered (Corinne et al., 2009). These vitamins, in particular vitamin B12, exhibit important roles in various biological events to maintain normal neural functions (Corinne et al., 2009; Hobbenaghi et al., 2012). Application of vitamin B complex or vitamin B12 has been shown to increase the number of Schwann cells and myelinated nerve fibers and the diameter of axons, and thereby promote the regeneration of myelinated nerve fibers and the proliferation of Schwann cells (Lopatina et al., 2011). Treatment with vitamin B complex or vitamin B12increases the expression of brain-derived neurotrophic factor (BDNF) in the injured sciatic nerves at both mRNA and protein levels, but it does not affect on the expression of glial cell-derived neurotrophic factor, neurotrophin-3, and interleukin-6; in addition, vitamin B complex and vitamin B12 have been shown to promote the regeneration and functional recovery of injured sciatic nerves through increasing BDNF expression (Sun et al., 2012). Supplementation of vitamin B12 may enhance peripheral nerve regeneration (Watanabe, 1994). High dose vitamin B12 has been shown to have the potential to treat peripheral nerve injury (Okada and Tanaka, 2010).
Omega-3 fish oil supplement — 1,000–2,000 milligrams a day
Glucosamine and chondroitin